MTORC1 FUNCTION IN HIPPOCAMPAL PARVALBUMIN INTERNEURONS: REGULATION OF FIRING AND LONG-TERM POTENTIATION OF INTRINSIC EXCITABILITY BUT NOT LONG-TERM CONTEXTUAL FEAR MEMORY AND CONTEXT DISCRIMINATION

Abstract Hippocampal CA1 parvalbumin-expressing interneurons (PV INs) play a central role in controlling principal cell activity and orchestrating network oscillations.PV INs receive excitatory inputs from CA3 Schaffer collaterals and local CA1 pyramidal cells, and they provide perisomatic inhibition.Schaffer collateral excitatory synapses onto PV

With the improvement of the conversion efficiency of LED chip and fluorescent material and the increasing demand Christmas for high-brightness light sources, LED technology has begun to move toward the direction of high-power.However, there is a huge problem that high-power LED must face with a large amount of heat generated by high power causing a

Sarcopenia is defined by the age-related loss of skeletal muscle quality, which relies on mitochondrial homeostasis.During aging, several mitochondrial features such as bioenergetics, dynamics, biogenesis, and selective autophagy (mitophagy) are altered and impinge on protein homeostasis, resulting in Control Key Board loss of muscle mass and funct

BackgroundAdolescents experience relatively more stress than other populations as they are facing rapid physical changes and adapting to complex social environments.However, access for this population to professional service providers is limited.Therefore, there is an increasing need for access to mental health services and new mental health care r